Abstract
Tert-alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagents mediated by commercially available lanthanum chloride-lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates.
Supplementary materials
Title
Supplementary material, procedures, characterization data
Description
Supplementary material, contains procedures, yields, tabulated spectra, NMR spectral images
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