Convenient Lanthanum-Mediated Synthesis of Bulky tert-Alkyl Amines from Nitriles

26 September 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Tert-alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagents mediated by commercially available lanthanum chloride-lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates.

Keywords

amine
lanthanum
bulky
synthesis

Supplementary materials

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Description
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Title
Supplementary material, procedures, characterization data
Description
Supplementary material, contains procedures, yields, tabulated spectra, NMR spectral images
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