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Catalytic coupling of 1,4-benzenedimethanol with ethanol for alcohol upgradation

26 August 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report here a catalytic method to upgrade 1,4-benzenedimethanol to 3-(4-(hydroxymethyl)phenyl)propan-1-ol via coupling of 1,4-benzenedimethanol with ethanol using a ruthenium catalyst. Through systematic optimization of catalytic conditions, a high TON of 400,000 has been achieved. Based on previous studies and those reported herein, we suggest that the reaction proceeds via a hydrogen-borrowing mechanism in a Guerbet-style process.

Keywords

ruthenium
guerbet coupling

Supplementary materials

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Description
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Supporting information
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Supporting information file contains details of catalytic experiments.
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Version History

Aug 26, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-qd9kk
D O I: 10.26434/chemrxiv-2024-qd9kk [opens in a new tab]

Funding

Engineering and Physical Sciences Research Council
EP/Y005449/1

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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