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Exploration of One-Pot, Tandem Sulfamoylation and Aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Heterocycles

20 August 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We show the first examples of one-pot, tandem sulfamoylation/aza-Michael reactions for the preparation of oxathiazinane heterocycles from linear alkenyl alcohol precursors. Our optimized protocols are tolerant of a variety of functional groups and provide products which are amenable for further transformations. The reactions scale well, and no special precautions are required to exclude air or ambient moisture.

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Version History

Aug 20, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-605fc
D O I: 10.26434/chemrxiv-2024-605fc [opens in a new tab]

Funding

National Institutes of Health
R35GM142499

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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