Abstract
Two low-cost reactors for aryllithium generation and trapping with an electrophile in flow have been developed for use with small quantities of limiting reagent (600 μmol) using reductions in flow rates as the approach to miniaturisation. To this end, a number of inexpensive, commercially available mixing elements were characterised via model lithium-halogen exchange reactions to determine their performance at low (< 5 mL min-1) flow rates. From these studies, a glass chip mixer, and 250 μm tee-pieces were identified for use at low flow rates and therefore incorporated into the aforementioned reactors. These reactors were demonstrated to be suitable for the successful lithiation and trapping of a selection of ArX substrates.
Supplementary materials
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Supplementary information
Description
Includes experimental methods, material sources, supporting chromatograms and spectra.
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Title
Mixer photos
Description
Photos and bill of materials for both reactors used in the work
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