Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Electrochemical trifluoromethylation of enamides under microflow conditions

02 August 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The development of sustainable trifluoromethylations of enamides is of great interest to the pharmaceutical industry. Herein, we demonstrate a sustainable direct electrochemical trifluoromethylation method in a microflow cell, using Langlois reagent, without the need of a supporting electrolyte, oxidants or any additive under mild conditions. This method can be applied to various substrates with a yield up to 84%.

Supplementary materials

Title
Description
Actions
Title
Electronic Supplementary Information
Description
ESI containing general experimental data, additional optimisation data, and characterisation of compounds.
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Electrochemical Trifluoromethylation of Enamides under Microflow Conditions [opens in a new tab]
Anna Vanluchene, Tomas Horsten, Eli Bonneure, Christian V. Stevens journal article
Organic Process Research & Development , Volume 28, Issue 11
Online publication date: Oct 22, 2024

Version History

Aug 02, 2024 Version 1

Metrics

389
244
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-069lr
D O I: 10.26434/chemrxiv-2024-069lr [opens in a new tab]

Funding

European Union’s Horizon 2022, Marie Skłodowska-Curie grant
101063994

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share