General and Versatile Synthesis of Highly Recyclable Chiral Phosphoric Acid Organocatalysts

29 July 2024, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The development of recyclable catalysts has gained more attention in recent years in order to minimize the environmental effect and the overall cost of catalytic processes. Some of the most broadly used chiral organocatalysts are BINOL-derived chiral phosphoric acids, making it necessary to develop efficient recycling strategies. While literature reports require up to 13 synthetic steps to access recyclable chiral phosphoric acids, here we report a general and concise 9-step approach to anthracene decorated heterogeneous chiral phosphoric acids (PS-Anth), which have shown high performance either in batch or continuous flow without observing catalyst degradation.

Keywords

chiral phosphoric acid
recyclable organocatalyst
organic synthesis
enantioselective catalysis

Supplementary materials

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Description
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Experimental supporting information
Description
Synthesis and characterization of organic compounds Synthesis and characterization of heterogeneous catalyst General procedures and methods
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