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Abstract
Nanotechnology has had a profound influence on human existence. Overcoming the many difficulties presented by various disorders, particularly neurological disorders (NDs), is a crucial approach. Various types of nanomaterials, including lipid nanoparticles, nanoliposomes, nano-micelles, polymer nanoparticles, and metal nanoparticles, along with different methods of transportation arrangements such as poly lactic o-glycolic acid, lactoferrin, and poly butyl cyanoacrylate, have the potential to greatly enhance the effectiveness, reduce the risk of negative outcomes, improve stability, and enhance the pharmacokinetics of many medications. Neurological disorders (NDs) are a subset of debilitating diseases that have a significant impact on a large population worldwide. Prior studies have shown that various formulations including nanotechnology, derived from a range of natural substances such as curcumin, quercetin, Ginkgo Biloba, and nigella sativa, significantly improve the well-being of persons with neurological disorders. The blood-brain barrier (BBB) is the primary obstacle preventing the passage of medications into the central nervous system (CNS), posing a challenge in the treatment of neurological disorders (NDs). . Engineered nanoparticles with altered physicochemical characteristics, ranging in size from 1 to 100 nm, can be utilized to enhance the effectiveness, cellular uptake, selective delivery, and distribution of specific particles to the brain. Nanoparticles derived from therapeutic plants and their constituents, known as phytomedicine from nano, have gained recognition for their abundant supply, ability to precisely target the brain, and reduced risk of adverse effects. These nanoparticles are increasingly important in the development of advanced neuro-therapeutics. This paper discusses the potential and ongoing advancements in using the combination of phytomedicine and nanotechnology for the treatment of neurological disorders. To summarize, herbal-based nanosystems, either alone or in combination with other drugs, demonstrate potential efficacy in the treatment of neurological disorders..
