A Rapid Pathway to Molecular Complexity: Palladium-Catalyzed Six-Fold Domino Process to Access Fused Polycyclic Framework

This study demonstrates an expedient strategy for the quick access of intriguing fused polycyclic frameworks through palladium-catalyzed six-fold domino crossover annulations of simple 1,2-bis(2-bromoaryl)ethynes and 1,2-diarylethynes. Remarkably, this strategy enables the construction of six-C−C bonds in a single-pot operation. In fact, this synthetic conversion takes up two successive domino pathways (i.e., via two consecutive catalytic cycles) to reach the targets and each of it contributes to the formation of three-C−C bonds. Significantly, this strategy exhibited good substrate scope and ena-bled the construction of C2-symmetric as well as unsymmetric polycyclic products.