Carbamoylation of azaarenes and olefins with formamides through dual photoredox/HAT catalysis

26 June 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Among the different methods to synthesize amides, radical amidation of suitable acceptors is appealing. In this context, we have developed a methodology for the photoinduced Minisci and Giese carbamoylation with readily available formamides. This approach avoids using less atom-efficient carbamoyl precursors (e.g., oxamic acids) and sacrificial oxidants, relying on dual photoredox/hydrogen atom transfer (HAT) catalysis.

Keywords

Minisci reaction
Giese reaction
carbamoylation
photoinduced
dual catalysis

Supplementary materials

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Supporting Information
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General methods and characterization
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