Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

What impact does tautomerism have on drug properties and development?

27 May 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This mini-review reports on effects that tautomerism has on predicted and clinically observed small-molecule properties important for drug design and drug behaviour in the patient. We present examples of both pharmacokinetics and pharmacodynamics effects. The importance of tautomerism on drugs’ formulation and possible interconversion of stereoisomers is also discussed.

Keywords

Tautomerism
Pharmacokinetics
Pharmacodynamics
Drug design
Drug properties

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

What impact does tautomerism have on drug discovery and development? [opens in a new tab]
Devendra K. Dhaked, Marc C. Nicklaus journal article
Expert Opinion on Drug Discovery
Online publication date: Jul 16, 2024

Version History

May 27, 2024 Version 1

Metrics

265
226
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-pfz2n
D O I: 10.26434/chemrxiv-2024-pfz2n [opens in a new tab]

Funding

NCI, NIH, Intramural Research Program
N/A
Department of Pharmacoinformatics, NIPER
N/A

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share