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Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling

24 May 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is functional group tolerant and compatible with complex molecules. Installation of the Ge moeity enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.

Keywords

germanium
click
copper
cycloaddition

Supplementary materials

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Supporting Information file
Description
Characterization data (PDF), copies of NMR spectra (PDF), crystal structure data (PDF). CCDC 2355570 (Compound 13) contains the supplementary crystallographic data for this study.
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Comment number 1, Kirill Zaitsev: Jun 02, 2024, 18:16

Compound of such type (germanyl triazoles) have been described earlier. See, https://doi.org/10.1002/asia.202300753

Version History

May 24, 2024 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-s7dht
D O I: 10.26434/chemrxiv-2024-s7dht [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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