Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling

24 May 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is functional group tolerant and compatible with complex molecules. Installation of the Ge moeity enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.

Keywords

germanium
click
copper
cycloaddition

Supplementary materials

Title
Description
Actions
Title
Supporting Information file
Description
Characterization data (PDF), copies of NMR spectra (PDF), crystal structure data (PDF). CCDC 2355570 (Compound 13) contains the supplementary crystallographic data for this study.
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.
Comment number 1, Kirill Zaitsev: Jun 02, 2024, 18:16

Compound of such type (germanyl triazoles) have been described earlier. See, https://doi.org/10.1002/asia.202300753