Additive-free Pd/In2O3 Catalyzed N-methylation of Primary Amides using Formic Acid

Here we report on the use of formic acid as a green and safe reagent for the N-methylation of primary amides in the presence of a Pd/In2O3 solid catalyst. No additive is needed and primary amides are selectively N-methylated in good to excellent yields. The reaction operates through a formylation/reduction pathway, leaving the amide carbonyl untouched.