The Evolving Landscape of Parkinson's Disease Research: Current Challenges and Future Outlook

25 April 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It occurs due to gradual loss of dopamine-producing brain cells, particularly in substantia nigra. The exact cause of Parkinson's disease is not fully understood, but it is believed to involve a combination of genetic and environmental factors. Currently available treatments provide symptomatic relief but do not halt disease progression. Research efforts are focused on developing disease-modifying therapies that target the underlying pathological mechanisms of PD. Advances in identification and validation of reliable biomarkers for PD hold promise for enhancing early diagnosis, monitoring disease progression, and assessing treatment response in clinical practice, in effort to alleviate the burden of this devastating disease. Research into PD is an active and evolving field, with ongoing efforts focused on understanding disease mechanisms, identifying biomarkers, developing new treatments, and improving patient care. In this paper, we analyze data from the CAS Content Collection to summarize the research progress in PD. We examine publication landscape in effort to provide insights into current knowledge advances and developments. We also review the most discussed and emerging concepts and assess the strategies to combat the disease. We explore genetic risk factors, pharmacological targets, and comorbid diseases. We inspect clinical applications of products against PD with their development pipelines and efforts for drug repurposing. The objective of this review is to provide a broad overview of the evolving landscape of current knowledge regarding PD, to outline challenges, and evaluate growth opportunities to further efforts in combating the disease.

Keywords

Parkinson’s disease
pathogenesis
aging
dopaminergic neuron
alpha-synuclein
Lewy bodies
protein aggregation

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.
Comment number 3, kim Lang: Nov 14, 2024, 18:39

I used TTFD, Amantadine, Anticholinergic, Dopamine agonist and Levodopa in the past though they helped a little for short period of time with enormous side effects and my Parkinson Disease symptoms frequently kept coming back but this time very bad and worsen due to the pharmaceutical treatments I was using. So! I had to decide to stop them all, and that was before I found out about MHC PD-50hc health protocol which I discovered on the internet, I was tagged on the MCH PD-50hc protocol immediately I ordered it from MHC which I was guided through. The MHC PD-50hc protocol drastically restore and revive my PD ill health to a good normal health though the damages PD has caused me, some still remains but I was guaranteed that they will gradually align with time which I started observing in the past 6 months now, I was told that my condition has been lifted that my PD won’t progress anymore and that i believe because many of my symptoms has stopped after using this MCH PD-50hc protocol that I got from www.madidaherbalcenter.weebly.com, the good news is I am back on my feet and can walk and work by myself now. You can go ahead and explore their site and seek their help if you need any;Email: [email protected]:  www.madidaherbalcenter.weebly.comfacebook page: https://facebook.com/madidaherbalcenter. Thank you all. 

Comment number 2, Patti Manners: Nov 04, 2024, 10:30

My husband was diagnosed of Parkinson’s Disease a couple of years ago, he had severe fatigue, difficulty with mobility and sleeping. He was placed on Sinemet 3 times daily, which helped but only for a short while. So we decided to try alternative treatment and began on PD-5 protocol, it has made tremendous difference for my husband, he had improved walking balance, muscle strength and he is now very active. His Parkinson’s is totally under control, we got the treatment from binehealthcenter. com. This treatment is a breakthrough for PWP!

Comment number 1, Caroline McGaughey: May 23, 2024, 05:40

My spouse was diagnosed with Parkinson's disease. His symptoms included excruciating calf pain, muscular aches, tremors, slurred speech, frequent falls, loss of balance, and trouble standing up from a seated posture. After six months on Senemet, Siferol was given to him in place of the Senemet. It was also at this period that he was diagnosed with dementia. He began seeing hallucinations and became detached from reality. With the doctor's approval, we stopped giving him Siferol and chose to try the Ability Health Center PD-5 program, which we had previously investigated. After three months of therapy, he has made significant progress. The illness has been completely contained. There are no symptoms of persistent twitching, weakness, tremors, hallucinations, or muscle soreness. The PD-5 Protocol was obtained from abilityhealthcentre. com. Though you still need to determine what works best for you, I thought I would share my husband's story in case it could be helpful. Greetings and prayers