Solving A Mystery with Classical and Dual Photoredox Catalysis: Application of Nickel in the Synthesis of Ergot Alkaloids

08 April 2024, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


A short synthesis of the ergot alkaloid lysergene and a formal total synthesis of lysergic acid diethylamide (LSD) under avoidance of palladium and including two nickel-catalyzed steps instead has been developed. A key intermediate of this approach has already been reported by Hendrickson et al. in 2004, yet the spectral data do not match, adding to doubts on the course of their route. While the final steps of the Hendrickson synthesis could not be reproduced, we were able to leverage the elusive intermediate


lysergic acid

Supplementary materials

Supporting Information
SI file with procedures, compound characterization data and spectra


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