Total synthesis of a peptide diatom sex pheromone bearing an unusual sulfated aspartic acid

29 March 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The peptide Sex Inducing Pheromone SIP+ bearing an unusual sulfated aspartic acid residue induces sexual reproduction in diatom populations. Herein, we report the first total synthesis of SIP+ using both a sulfated building block approach and a SPPS compatible late-stage sulfation strategy to assemble the natural product. The modular approaches provide concise routes to useful quantities of the natural product for future SAR investigations examining the role of SIP+ in diatom biology.


Total synthesis
Sex Inducing Pheromone


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.