Rhodium-Promoted C-H Activation/ Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes

25 March 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


As discovered by the previous selection outcomes, we developed a Rhodium-promoted C-H activation/ annulation reaction of DNA-linked terminal alkyne and aromatic acid. This reaction exhibits excellent efficiency with high conversions and a wide broad sub-strate scope. Most importantly, the unique DEL-compatible condition provides a better scenario to yield an isocoumarin scaffold compared to conventional organic reaction condition, and this newly developed on-DNA method has confirmed its feasibility in preparing DNA-encoded libraries.


DNA-encoded library technology
DNA-encoded library
C-H activaton
oxidative annulation
terminal alkyne


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