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Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration

20 March 2024, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

IsoDMT analogs with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen-autotransfer (HA) alkylation and tested in combination with natural and unnatural clavine alkaloids in a model of light-induced retinal degeneration for protection against retinal degeneration. As assessed with OCT and ERG, three compounds showed better efficacy than positive-control bromocriptine at equivalent systemically administered doses. These studies provide further insight into the role that 5-HT receptors play in ocular diseases.

Keywords

Serotonin receptor agonists
ergot alkaloids
ophthalmology
retinal diseases
LIRD

Supplementary materials

Title
Description
Actions
Title
SI for Supporting Information Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration
Description
Experimental Procedures and Biological Data
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Version History

Mar 20, 2024 Version 2

Version Notes

change in order of authors

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-nkzks-v2
D O I: 10.26434/chemrxiv-2024-nkzks-v2 [opens in a new tab]

Funding

PROFI6
Boehringer-Ingelheim
Research Council of Finland
346295
Business Finland
Emil Aaltonen Foundation
Sigrid Jusélius Foundation
Päivikki and Sakari Sohlberg Foundation
Finnish Eye and Tissue Bank Foundation
Retina Registered Association
Sokeain Ystävät/De Blindas Vänner Registered Association

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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