Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration

20 March 2024, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

IsoDMT analogs with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen-autotransfer (HA) alkylation and tested in combination with natural and unnatural clavine alkaloids in a model of light-induced retinal degeneration for protection against retinal degeneration. As assessed with OCT and ERG, three compounds showed better efficacy than positive-control bromocriptine at equivalent systemically administered doses. These studies provide further insight into the role that 5-HT receptors play in ocular diseases.

Keywords

Serotonin receptor agonists
ergot alkaloids
ophthalmology
retinal diseases
LIRD

Supplementary materials

Title
Description
Actions
Title
SI for Supporting Information Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration
Description
Experimental Procedures and Biological Data
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Mar 20, 2024 Version 2

Version Notes

change in order of authors

Metrics

516
326
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-nkzks-v2
D O I: 10.26434/chemrxiv-2024-nkzks-v2 [opens in a new tab]

Funding

PROFI6
Boehringer-Ingelheim
Research Council of Finland
346295
Business Finland
Emil Aaltonen Foundation
Sigrid Jusélius Foundation
Päivikki and Sakari Sohlberg Foundation
Finnish Eye and Tissue Bank Foundation
Retina Registered Association
Sokeain Ystävät/De Blindas Vänner Registered Association

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share