Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration

20 March 2024, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

IsoDMT analogs with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen-autotransfer (HA) alkylation and tested in combination with natural and unnatural clavine alkaloids in a model of light-induced retinal degeneration for protection against retinal degeneration. As assessed with OCT and ERG, three compounds showed better efficacy than positive-control bromocriptine at equivalent systemically administered doses. These studies provide further insight into the role that 5-HT receptors play in ocular diseases.

Keywords

Serotonin receptor agonists
ergot alkaloids
ophthalmology
retinal diseases
LIRD

Supplementary materials

Title
Description
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Title
SI for Supporting Information Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration
Description
Experimental Procedures and Biological Data
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