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Abstract
Calcium ion (Ca2+) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visi-ble light-activated Ca2+ chelators with high quantum yields of 0.39, 0.52, and 0.83. The chelators demonstrated an over 10^5-fold increase in Ca2+ binding affinity upon irradiation. These chelators are efficiently triggered by biologically safer wavelengths, rendering them excellent candidates for use in neuroscientific research and medicine.
Supplementary materials
Title
Highly Efficient Visible Light-Induced Ca2+ Chelation
Description
This work introduces three visible light-triggered chelators that show a near million-fold enhanced binding of calcium ions. The highest reported of the three chelators exhibited a quantum yield of 0.83 when irradiated with blue light. DFT computations supported the experimentally observed enhanced binding of calcium ions upon irradiation.
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