Catalytic Ortho C-H Methylation and Trideuteromethylation of Ar-ylthianthrenium Salts via the Catellani Strategy

26 February 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We reported a Pd/NBE cooperative catalyzed ortho C−H methylation and trideuteromethylation of arylthianthrenium salts, enabling the efficient synthesis of a wide variety of (trideutero)methylated arenes in moderate to good yields. The method demonstrates excel-lent tolerance towards functional groups, scalability, and potential extension to the late-stage functionalization of biorelevant mole-cules. In combined with C−H thianthrenation of arenes, this approach provides an effective method for the site-selective C−H (trideutero)methylation of arenes. Additionally, this reaction represents the first example of a Catellani reaction involving aryl sul-fonium salts.


magic methyl
Catellani reaction
arylthianthrenium salts
Late-Stage Modification

Supplementary materials

Catalytic Ortho C-H Methylation and Trideuteromethylation of Arylthianthrenium Salts via the Catellani Strategy
For a detailed description of the synthesis of starting materials and final products, see the Supporting Information.


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.