In vitro evaluation of the antiparasitic activity of p-coumaric acid prenylated derivatives

22 February 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 (methyl 3,5-diprenyl-4-prenyloxycinnamate) was the most active against L. amazonensis (IC50 = 45.92 µM) and S. mansoni (IC50 = 64.25 µM). None of the tested compounds killed S. mansoni adult worms. Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.


artepillin C
Leishmania amazonensis
plicatin B
Schistosoma mansoni

Supplementary materials

Supporting Information - NMR and MS
This file contains NMR (1H, 13C, and DEPT 135) spectra and data of compounds 1-8, as well as their mass spectra (HR-ESI-MS).


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.