Rh(III)-Catalyzed Regioselective C8-alkenylation of isoquinolones with methoxyallene: A Facile Access to aldehyde bearing isoquin-olones

A simple and facile access to isoquinolone aldehyde scaffolds has been achieved through a rhodium-catalyzed reaction between isoquinolone and methoxyallene. Herein, methoxyallene serves as an acrolein equivalent, resulting in this unique functionalization. Furthermore, the compatibility with natural complex and drug molecules underscores the sig-nificance of this developed protocol. Based on kinetic studies and several control reactions, a plausible reaction mecha-nism has also been proposed for this regioselective transformation.