N-Heterocyclic carbene-catalyzed SuFEx reactions of functionalized secondary alcohols

16 February 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An organocatalytic Sulfur (VI)-fluoride exchange (SuFEx) reaction of secondary alcohols is reported. Under the catalysis of 10 mol% NHC/MS 4Å, both trifluoromethyl and difluoromethyl benzyl alcohols reacted with aryl sulfonyl fluorides to produce the corresponding sulfonates in moderate to high yields.

Keywords

N-Heterocyclic carbene
Sulfur (VI) fluoride exchange
click chemistry
sulfonates
secondary alcohols

Supplementary materials

Title
Description
Actions
Title
Supporting Information
Description
Includes general information, general procedure for the synthesis of sulfonates and copies of NMR spectra.
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.