Ru(II)-catalyzed C7 trifluoromethylthiolation and thioaryla-tion of indolines using bench-stable reagents

A Ru(II)-catalyzed C(sp2)-H trifluoromethylthiolation and thioarylation of indolines using bench-stable reagents have been explored. Diversely substituted indolines were successfully functionalized at C7 position in good to excellent yields. To support the proposed reaction pathway, radical quenching, deuterium labeling, KIE experiments, and reac-tion order determination were performed. Gram-scale synthesis and post-transformation of the synthesized product have also been performed to demonstrate the applicability of the developed catalytic protocol.