Desymmetrization of Diboron (4) by a Trifluorination B-Masking Strategy: Practical Synthesis of Unsymmetrical Diboron Species

13 February 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Herein, we report a straightforward practical and simple method for efficiently synthesizing a BF3- containing unsymmetrical diboron salts. This method involves the direct desymmetrization of commercially available diboron (4). This desymmetrization is based on a selective B-masking strategy via nucleophilic trifluorination, providing the elusive diborons bearing a trifluoroborate group. The synthetic utility of these salts is demonstrated through various examples of (sequen-tial) B-ligand interconversions, enabling the synthesis of unsymmetrical diboron derivatives. These products, which serve as valuable building blocks, are obtained in high yields.


diboron (4)


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