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Abstract
This study investigates the synthesis of a molybdenum complex with a notable capacity to safeguard DNA against radiation-induced damage. Comprehensive analyses reveal that not only the complex [cis-MoO2(OV)2] exhibits a significant radioprotective efficacy which can shield 89% of damaged CT DNA but also the ligand (OV) show a good amount of protection. At a concentration of 2 mM and a radiation dosage of 20 Gy, cis-MoO2(OV)2 demonstrates the ability to protect approximately 85% of radiation-induced damage to plasmid (pUC19) DNA also from gamma rays. These findings underscore the considerable potential of cis-MoO2(OV)2 as an effective radioprotector for normal tissues in radiotherapy. Notably, the complex's capacity to mitigate DNA damage caused by radiation holds significant promise, presenting implications for the advancement of novel therapeutic strategies across various medical conditions.
