Alkoxy Substituted Brominated closo-Dodecaborates with Functionalized Aliphatic Spacers

15 February 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The utilization of dodecaborate boron clusters, B12X122– (X = Cl, Br, or I), as membrane carriers has been demonstrated recently, and their activity is known to be due to their superchaotropic nature. In this work, the mono alkylation of [B12Br11OH]2– to functionalize it with an aliphatic spacer was developed with a view to expanding the known chemical space of membrane carriers based on B12Br122–. A new and improved facile route for the preparation of [B12Br11OH]2–, which is an important precursor to other [B12Br11OR]2– species, is reported. Various alkoxylated [B12Br11O(CH2)5Z]2– (Z = OH, N(CO)2C6H4, CN and N3) derivatives were prepared via a divergent synthesis based on [B12Br11O(CH2)5Br]2–. One of the newly synthesized compounds was utilized as a membrane carrier and its impact on cell viability was examined.


Boron cluster
Membrane transport

Supplementary materials

Supporting Information
Supporting Information for the main text


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