Accelerated Analysis of the Electrochemical Production Route for Biomass-derived Adiponitrile

24 January 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Electrochemical transformation of biomass feedstocks offers a promising route for sustainable production of fuels and chemicals, enhancing integration with renewable energy sources. Adiponitrile, a key intermediate in Nylon 6,6 production, is mainly produced through thermochemical processes or methods relying fossil fuel feedstocks. Alternatively, it can be produced through Kolbe coupling of biomass-derived 3-cyanopropanoic acid, with its practical implementation hinging on understanding and controlling factors that dictate reaction selectivity. In this study, we establish relationships between electrolyte composition, electrochemical conditions, and performance metrics in this approach, achieving a maximum Faradaic efficiency of 40% towards adiponitrile at current densities up to 500 mA cm-2. Implementing a semi- autonomous high-throughput electrochemical workflow, we tested hundreds of reaction conditions, accelerating the exploration of reaction parameters. Limitations and guidelines obtained from this study apply to a range of electrochemical decarboxylation reactions, and the accelerated research approach shows potential for speeding the development of sustainable electrochemical processes.


nylon 66
chemical manufacturing


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.