Caged Gold Nanostars: A novel plasmonic nanoplatform with theranostics applications

Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS particles and highlight the benefits of the galvanic replacement-free approach. FEM simulations explore the enhanced plasmonic properties of this novel nanoparticle morphology. Finally, in a proof-of-concept study, we successfully demonstrate in vivo hyperspectral imaging and photothermal treatment of tumors in a mouse model with the C-GNS nanoplatform.