Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hy-pothesis Involves a Finely Tuned Reactivity of C3 Unit: a High-Throughput Experimentation Approach

17 January 2024, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A rapid analysis of mass spectrometry data generated from 96 multicomponent reactions using a herein-provided chemoinformatic workflow, have pinpointed relevant conditions tuning the reactivity of acrolein to fulfill Baldwin and Whitehead’s manzamine alkaloids biosynthetic hypothesis. This strategy can become part of a general method for the analysis of information-rich high-throughput experiments of multicomponent reactions applied to natural product biosynthetic scenario

Keywords

HTE
Multicomponent reactions
Natural Products
Alkaloids
Molecular Networking
Baldwin
Manzamine

Supplementary materials

Title
Description
Actions
Title
Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hypothesis Involves a Finely Tuned Reactivity of C3 Unit: a High-Throughput Experimentation Approach
Description
Supporting information
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Jan 17, 2024 Version 2

Version Notes

A chemoinformatic workflow has been designed to process the outputs of MZmine 3 and to visualize ractivity patterns on heatmaps

Metrics

857
485
1
Views
Downloads

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-nk2cs-v2
D O I: 10.26434/chemrxiv-2022-nk2cs-v2 [opens in a new tab]

Funding

ANR
ANR-19-CE07-0002-01

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share