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Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hy-pothesis Involves a Finely Tuned Reactivity of C3 Unit: a High-Throughput Experimentation Approach

17 January 2024, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A rapid analysis of mass spectrometry data generated from 96 multicomponent reactions using a herein-provided chemoinformatic workflow, have pinpointed relevant conditions tuning the reactivity of acrolein to fulfill Baldwin and Whitehead’s manzamine alkaloids biosynthetic hypothesis. This strategy can become part of a general method for the analysis of information-rich high-throughput experiments of multicomponent reactions applied to natural product biosynthetic scenario

Keywords

HTE
Multicomponent reactions
Natural Products
Alkaloids
Molecular Networking
Baldwin
Manzamine

Supplementary materials

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Title
Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hypothesis Involves a Finely Tuned Reactivity of C3 Unit: a High-Throughput Experimentation Approach
Description
Supporting information
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Version History

Jan 17, 2024 Version 2

Version Notes

A chemoinformatic workflow has been designed to process the outputs of MZmine 3 and to visualize ractivity patterns on heatmaps

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License

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BY
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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-nk2cs-v2
D O I: 10.26434/chemrxiv-2022-nk2cs-v2 [opens in a new tab]

Funding

ANR
ANR-19-CE07-0002-01

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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