1-Cyano-1,2-benziodoxol-3(1H)-one

This comprehensive review discusses the properties, synthesis, and applications of 1-cyano-1,2-benziodoxol-3(1H)-one, a versatile cyanating agent. Various preparative methods are detailed, highlighting its synthesis through different reactions. The review emphasizes its stability and safe handling, making it a preferred choice over other cyanating agents due to its lower toxicity and ease of use. It plays a crucial role in electrophilic cyanation reactions, contributing to the synthesis of diverse organic molecules, including biologically active compounds and pharmaceuticals. The article also explores its application in metal-free, photoredox, and electrochemical methods, underscoring its broad utility in synthetic chemistry. The versatility of 1-cyano-1,2-benziodoxol-3(1H)-one is further demonstrated in its application in the synthesis of metal complexes and its potential in lignin degradation and heterocycle formation. The review concludes by comparing it with other hypervalent iodine reagents, highlighting its superior performance in various cyanation reactions.