A platform approach to mechanically caged molecules

02 January 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Inspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is “switched on” by breaking the mechanical bond have been reported. However, to date, each example uses a bespoke chemical design. Here we present a platform approach to mechanically caged structures wherein a single macrocycle precursor is diversified at a late stage to include a range of trigger units that control ring opening in response to enzymatic, chemical, or photochemical stimuli. We also demonstrate that our approach is applicable to other classes of macrocycles suitable for rotaxane and catenane formation.

Keywords

rotaxane
catenane
supramolecular
self-immolative

Supplementary materials

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