Abstract
A three-component synthesis of alpha-substituted sulfonamides from aryl aldehydes, primary sulfonamides and (hetero)arenes is described. This transformation enables a straightforward and modular synthesis of pharmaceutically relevant scaffolds in good yields. The direct functionalization of C(sp2)-H bonds via cobalt-catalyzed C-H-activation offers an appealing and atom-economical alternative to classical methods for the synthesis of alpha-arylated amines such as the Petasis or Mannich-type reactions.
Supplementary materials
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Supporting Information
Description
Experimental details, spectral data and copies of NMR spectra for all new compounds
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Title
Primary NMR Data
Description
Primary NMR data files for all final compounds 4-6 and the Cp*Co-catalysts
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