Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.

22 December 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The solventless synthesis of peptides from unactivated amino acids was performed in a twin-screw extruder. The general method was applied to the preparation of dipeptides and tripeptides. Aspartame, a synthetic dipeptide, was also prepared in a continuous mode on large scale.

Keywords

peptide
aspartame
coupling reaction
mechanochemistry
flow chemistry
reactive extrusion
twin-screw extruder
tse
ball-mill
epimerization-free

Supplementary materials

Title
Description
Actions
Title
Synthesis of peptides by reactive extrusion. Application to the sustainable preparation of aspartame.
Description
Supporting information : Procedures, spectral data, spectra
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