Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.

Tharwat Mohy El-Dine; Matthieu Lavayssiere; Hélène Adihou; Gilles Subra; Thomas-Xavier Métro; Olivier Ludemann-Hombourger; Frédéric Lamaty

doi:10.26434/chemrxiv-2023-2hhhk

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Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.

22 December 2023, Version 1

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Abstract

The solventless synthesis of peptides from unactivated amino acids was performed in a twin-screw extruder. The general method was applied to the preparation of dipeptides and tripeptides. Aspartame, a synthetic dipeptide, was also prepared in a continuous mode on large scale.

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Title

Synthesis of peptides by reactive extrusion. Application to the sustainable preparation of aspartame.

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Supporting information : Procedures, spectral data, spectra

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Mar 01, 2024 Version 2

Dec 22, 2023 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv-2023-2hhhk

Funding

PolyPeptide Group

Centre National de la Recherche Scientifique

University of Montpellier

Chimie Balard Cirimat Carnot Institute

ANR 16 CARN 0008-01

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

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The author(s) have declared ethics committee/IRB approval is not relevant to this content

Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame.

Authors

Abstract

Keywords

Supplementary materials

Comments

Version History

Metrics

License

DOI

Funding

Author’s competing interest statement

Ethics

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