Decarboxylative C N coupling of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks

18 December 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Described herein is our effort towards achieving the decarboxylative functionalization of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks. When compared with the non-fluorinated bicyclo[1.1.1]pentane (BCP) analogues, we discovered divergent reactivities. This is the first successful decarboxylative coupling of BCP-F2 building blocks reported via photoredox mechanism.


Decarboxylative coupling
C-N coupling


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