![Author ORCID: We display the ORCID iD icon alongside authors names on our website to acknowledge that the ORCiD has been authenticated when entered by the user. To view the users ORCiD record click the icon. [opens in a new tab]](https://chemrxiv.org/engage/assets/public/chemrxiv/images/logos/orcid.png)
Abstract
A highly diastereoselective synthesis of spiroisoindolinones from enamides and 3-hydroxy-isoindolinones is reported.
The reaction proceeds rapidly in the presence of para-toluenesulfonic acid as Brønsted acid-catalyst and affords a variety of densely substituted spiroisoindolinoes with three contiguous stereogenic centers in high yields (up to 98%) and diastereoselectivities (up to dr >98:<2:0:0).
Supplementary materials
Title
Supporting Information File 1
Description
Experimental details, spectral data, DOIs for data referring to this study (deposited in the chemotion repository: https://www.chemotion-repository.net/), and copies of NMR spectra for all new compounds
Actions
Title
Supporting Information File 2
Description
Information on the physical availability of the target com-pounds from the Molecule Archive at KIT (https://compound-platform.eu/home).
Actions
Title
X ray data
Description
cif and checkcif files for compounds 4a (CCDC 2311285), 4h (CCDC 2311286) and 4p (CCDC 2311287)
Actions
