"Liq. Hydrogen carrier and C1 source – Methanol” mediated Selective N-Methylation of Urea via Transfer Hydrogenation catalyzed by Pd/C

We report the catalytic transfer hydrogenation of urea derivatives using green hydrogen from methanol, which is the most ambitious effort in this hydrogenation world. On enlarging this methodology, selective N-methylated amines achieved from urea which are widely featured in drugs, natural products, paints etc. Moreover, this methodology making a sustain-able alternative pathway for the synthesis of selective methylated derivative from CO2 derived compound. The key to the success of this transformation is the use of a commercially available Pd/C heterogenous catalyst and Methanol which act as both H2 and C1 sources. In addition, several control experiments with the plausible intermediates were performed to analyze this novel pathway. This transformation proceeds in an environmentally friendly greener protocol and high at-om-economy.