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Abstract
Pure shift NMR experiments greatly enhance spectral resolution by collapsing multiplet structures into singlets and, with water suppression, can be used for aqueous samples. Here, we combine ultra-clean pure-shift NMR (SAPPHIRE) with two different internally encoded water suppression schemes to achieve optimal performance for small molecule and macrocyclic peptide pharmaceuticals in water and acetonitrile-water mixtures.
Supplementary materials
Title
Electronic supporting information
Description
Pulse sequences and additional spectra for "Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples"
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