Continuous flow synthesis of atom-precise platinum clusters

24 November 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Subnanometer clusters with precise atom numbers hold immense potential for applications in catalysis, as single atoms can significantly impact catalytic properties. Typically, inorganic clusters are produced using batch processes with high dilutions, making the scale-up of these processes time-consuming and its reproducibility challenging. While continuous-flow systems have been employed for organic synthesis and, more recently, nanoparticle preparation, these approaches have only rarely been applied to cluster synthesis. In a flexible, continuous flow synthesis platform, we integrate multiple continuously stirred tank reactors (CSTR) into a cascade to synthesize clusters with a precise number of atoms, demonstrating the potential of this approach for atom precise cluster synthesis and expanding the application of continuous-flow systems beyond organic synthesis.


continuous flow synthesis
continuously stirred tank reactor (CSTR)

Supplementary materials

Suplementary Information
TEM images, mass spectra, RTD profiles


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