A Golden Touch in the Design of Porphyrin Metallacages as Multifaceted Anticancer Agents

09 November 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The use of three-dimensional self-assembled metallacages (MCgs) as theranostic platforms holds great promise. This work reports on the integration of a gold(III) porphyrin scaffold into a prismatic metallacage structure and explores its application for photodynamic therapy (PDT) of cancer in vitro. Not only the new metallacage retains the photosensitizing properties of the gold porphyrin, but unexpectedly, it also shows remarkable selective stabilization of guanine-quadruplexes (G4) structures as validated anticancer drug targets.


Photodynamic therapy
guanine quadruplexes (G4)
Drug delivery systems
Gold compounds

Supplementary materials

SI_Gold metallacages
Experimental methods, and supplementary data: NMR spectra, MS spectra, UV-Visible absorption spectra, stability studies, additional figures and tables.


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