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Abstract
A new type of diborate clathrochelate (cage) ligand featuring nine inwardly pointing nitrogen donors that form a rigid cavity is presented here. The cavity size and high denticity (up to 9) make this cage a very attractive delivery vehicle for large radionuclides in nuclear medicine. Metal complexes of this cage are stable to air and water (neutral pH) indefinitely and display extremely high thermal stability (> 400 ⁰C). Lanthanide uptake by the cage occurs rapidly in solution at room temperature, even at very low concentrations (10-5 M, ESI-MS) and once complexed, the lanthanide ions are not displaced.
Supplementary materials
Title
Supporting Information
Description
Section 1 Synthetic procedures 3
Section 2 Selected NMR spectra 6
Section 3 Thermogravimetric analysis for K2[3a] 11
Section 4 X-ray crystallographic results 12
Section 5 UV-Vis spectroscopy 48
Section 6 Fluorescence spectroscopy for 5-NO3 49
Section 7 Electrospray mass spectrometry results 52
References 60
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