Pd-Catalyzed Intermolecular Si–O Formation via Si–C Activation

25 October 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The development of efficient Si–O bond formation reaction with 100% atom-economy, excellent functional group tolerance and broad scope under mild conditions is highly desired due to the prevalence of silanol, silyl ether and their derivatives in synthetic chemistry and material science. Here, we have realized the Pd-catalyzed Si–O formation reaction via a Si–C activation approach with 100% atom-economy by employing silacyclobutanes (SCBs) and various hydroxy-containing substrates, including water, alcohols, phenols, and silanols. This protocol features a broad substrate scope, remarkable functional compatibility, and mild conditions, providing a series of silanols, silyl ethers in high efficiency. Notably, this protocol could also be used for selective protection of hydroxy functionalities, and for the access of a class of novel polymers containing Si–O main chain. Preliminary mechanistic studies unveiled that this reaction underwent a Pd-catalyzed concerted ring-opening mechanism.


Si–O formation
Si–C activation
silyl ether

Supplementary materials

Supporting Information-PdSi-OFormation
Supporting Information


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