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Abstract
Subtype-selective ligands with photoswitchable properties are highly desired for photopharmacology of G protein-coupled receptors (GPCRs). We developed photoswitchable ligands targeting adenosine A2A receptor (A2AR), a GPCR subtype. Spatiotemporal activation of A2AR was successfully demonstrated in living cells using the photoswitchable ligand.
Supplementary materials
Title
Photoresponsive adenosine derivatives for optical control of adenosine A2A receptor in living cells
Description
Subtype-selective ligands with photoswitchable properties are highly desired for photopharmacology of G protein-coupled receptors (GPCRs). We developed photoswitchable ligands targeting adenosine A2A receptor (A2AR), a GPCR subtype. Spatiotemporal activation of A2AR was successfully demonstrated in living cells using the photoswitchable ligand.
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