Correspondence on “Organo-Mediator Enabled Electrochemical Deuteration of Styrenes”

The recently reported electrochemical, organo mediator enabled deuteration of styrenes, a reaction referred to as “electrochemical deuterium atom transfer”, differs mechanistically from reported direct electrochemical hydrogenations/deuterations only by a mediated, homogeneous SET to the substrates. By comparing direct vs. mediated processes in general and for styrene reduction, we display that Qiu’s work does not change the concept of this chemistry. Experiments with mediators and the direct reduction of examples from the reported scope show that even electron-rich substrates can be reduced when our direct protocol, published six months before Qiu’s work, is applied.