Synthesis of Sustainable and Robust Heterogeneous TEMPO Catalyst utilizing Activated Carbon for Aerobic Alcohol Oxidation

18 October 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The selective oxidation of alcohols is a crucial process in organic chemistry, but current methodologies have limitations such as pollution and over-oxidation. The use of 2,2,6,6-tetramethylpiperidine oxide (TEMPO) as a catalyst offers a promising approach for selective aerobic alcohol oxidation. However, the high cost of TEMPO and difficulty in catalyst recycling hinder its industrial application. This study focuses on developing a sustainable and robust heterogeneous TEMPO catalyst by immobilizing TEMPO on activated carbon (AC) through ozonation and reductive amination. The surface modification of AC through ozone carbonylation is explored, and a green and safe process is established using water as a dispersing and heat-shifting medium. The TEMPO-functionalized AC as a heterogeneous catalyst is characterized using various analytical techniques, and its catalytic performance is evaluated for continuous aerobic alcohol oxidation in a micro-packed bed reactor. The results demonstrate an extended catalyst lifetime (turnover number reaches 1465.0 for benzyl alcohol oxidation) and significant potential for industrial applications.


heterogeneous catalysis
aerobic alcohol oxidation
surface modification
activated carbon

Supplementary materials

Supplementary Information
Supplementary Information for this study


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.