Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization

A system that requires slurry handling such as reactive crystallization is not usually compatible with continuous flow synthesis due to the risk of clogging. Here we suggest the use of a Taylor vortex flow reactor to achieve the robust process for imination with reactive crystallization under continuous flow conditions. A Taylor vortex flow reactor realizes high shear stress and mixing efficiency, which accelerate the timing for nucleation of target imines and enable precise control of nucleation in reactive crystallization. A Taylor vortex flow reactor also mitigates the risk of adhesion to the flow reactor and clogging in reactive crystallization.