Synthesis and Biological Activity of Penaresidins A and B, Penazetidine A, and Related Analogs

16 October 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Since the first reports of their isolation, the penaresidins A and B together with penazetidine A and related analogs have attracted interest from the synthetic community for their unique structural features, specifically the highly functionalized azetidine core. This review provides a comprehensive overview of the biological activity of the penaresidins, penazetidine, and their analogs together with reported synthetic strategies developed since their isolation.


total synthesis
marine sponge


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