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Synthesis and Biological Activity of Penaresidins A and B, Penazetidine A, and Related Analogs

16 October 2023, Version 1
Review
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Since the first reports of their isolation, the penaresidins A and B together with penazetidine A and related analogs have attracted interest from the synthetic community for their unique structural features, specifically the highly functionalized azetidine core. This review provides a comprehensive overview of the biological activity of the penaresidins, penazetidine, and their analogs together with reported synthetic strategies developed since their isolation.

Keywords

total synthesis
azetidine
penaresidin
sphingolipid
marine sponge

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Version History

Oct 16, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-1k9ls
D O I: 10.26434/chemrxiv-2023-1k9ls [opens in a new tab]

Funding

National Science Foundation
NSF CHE-1654223

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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