Fe-Electrocatalytic Deoxygenative Giese Reaction

29 September 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups. The advancement of efficient conversion reactions holds significant importance in medicinal and process chemistry. In this report, we present a redox-neutral Giese reaction via anodic oxidation to generate phosphonium ions and cathodic reduction to yield low-valent Fe catalysts. This reaction constitutes a ground-breaking account of a redox-neutral reaction utilizing Fe-catalyst and electrochemistry. It will facilitate the exploration of diverse novel reactions employing this redox cycle in the future.


Deoxygenative Giese Reaction

Supplementary materials

Supporting Information
Experimental Procedures and Characterization of Compounds


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