Transition-metal free boron triiodide-mediated reduction of nitroarenes from simple borohydride reagents

22 September 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The reduction of nitroarenes using KBH4 and I2 is described. BI3 is generated in situ, which was shown to be the active reductant. Conditions were optimized for BI3 generation, and then applied to a wide range of nitroarenes, including traditionally challenging substrates. The method constitutes a practical reduction option which produces low toxicity boric acid and potassium iodide upon workup.

Keywords

Nitroarene reduction
boron chemistry

Supplementary materials

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Description
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Supplementary Info
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Reaction protocols and spectroscopic characterization data
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