Ni-Catalyzed Enantioselective Decarboxylative Acylation: Rapid, Modular Access to a-Amino Ketones

13 September 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A new approach to the enantiocontrolled synthesis of alpha-amino ketone derivatives is disclosed by employing a decarboxylative acylation strategy. Thus, when an acyl chloride and an alpha-amido-containing redox-active ester are exposed to Ni-catalysis, a chiral ligand, and metal reductant, alpha-amido ketones are produced in good yield and high ee. The reaction exhibits broad substrate scope, can be easily scaled up, and is applied to dramatically simplify the synthesis of several known structures.


enantioselective synthesis
ni catalysis
cross coupling

Supplementary materials

Supporting information
spectra, procedures, background information


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