Potent activity of Metal-Organic Framework nanoparticles loaded by hydrophobic natural products via one-pot synthetic method against pancreatic cancers

12 September 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Metal-organic frameworks (MOFs) have been recently proposed as a new nanoscale drug delivery vector posing significant surface area and tunable chemo physical properties. The main procedure of encapsulation of anticancer drugs into the MOFs are post synthetic methods (PSM), however that is time/energy consuming and often not be reproducible in large scale. Further, PSM method would not be applicable without coating due to the burst drug release. Herein, we report a new strategy of incorporating of hydrophobic natural drugs into zirconium terephthalate MOF UiO-66 via one-pot synthetic route. The drugs are added by one-pot solvothermal method and uniformly distributed throughout the MOFs surfaces. Potency of formulation showed a 7-fold increase compared to PSM MOFs against 3D cultured pancreatic cancers and can be applicable for other hydrophobic drugs.


Pancreatic cancer
Nano particles
drug delivery


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.